Environmental Chemicals: Evaluating Low-Dose Effects
نویسندگان
چکیده
منابع مشابه
Environmental Chemicals: Evaluating Low-Dose Effects
Around the world, large-scale biomonitoring programs have provided extensive information about human exposure to a large number of environmental chemicals (Barr et al. 2010; Bilau et al. 2008; Churchill et al. 2001; Woodruff et al. 2011). As these programs extend to look at vulnerable populations, including pregnant women, fetuses, and the elderly, our knowledge of the widespread distribution o...
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I am an academic scientist who has worked for nine years on issues related to endocrine disruptors, including assessments of human exposures, meta-analyses of published literature, and benchwork assessing the effects of chemicals on development, behavior, reproduction, and other endpoints in rodents and aquatic animals. My PhD is in Cell, Molecular and Developmental Biology, although my work is...
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For decades, studies of endocrine-disrupting chemicals (EDCs) have challenged traditional concepts in toxicology, in particular the dogma of "the dose makes the poison," because EDCs can have effects at low doses that are not predicted by effects at higher doses. Here, we review two major concepts in EDC studies: low dose and nonmonotonicity. Low-dose effects were defined by the National Toxico...
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Humans are exposed to a large number of environmental chemicals in their daily life, many of which are readily detectable in blood or urine. It remains uncertain if these chemicals can cause adverse health effects when present together at low doses. In this study we have tested whether a mixture of 27 chemicals administered orally to juvenile male rats for three months could leave a pathophysio...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 2012
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.1205179